Comprehensive Introduction
2-Methyltetrahydrofuran (2-MeTHF) is a high‑performance, bio‑based solvent produced by Shandong Yino Biologic Materials Co., Ltd. It's made from renewable biomass through the high‑temperature hydrogenolysis of furfural - a key chemical derived from pentose sugars in agricultural byproducts like corn cobs and sugarcane bagasse - making it a perfect fit for today's sustainable chemistry goals. With a boiling point of 79 °C, low water solubility, and weak coordination, our 2‑MeTHF offers up to 99.5% purity and contains ≤10 ppm of peroxides thanks to the addition of a BHT stabilizer. Compared to traditional tetrahydrofuran (THF), it's safer, more thermally stable, and even delivers a 44% lower carbon footprint. Plus, with an annual production capacity of 15,000 tons, we ensure a reliable global supply.
In Grignard reactions, 2‑MeTHF really stands out. Its weak coordination boosts the activity of Grignard reagents - helping push yields up to 98% - while also tolerating trace amounts of water (≤0.1%), which means there's no need for ultra‑dry conditions. And because it forms an azeotrope with water, solvent recovery rates can hit 85%, cutting costs in the process. This versatile solvent has already been used in the synthesis of the antimalarial drug chloroquine phosphate, the development of OLED materials, and a wide range of other applications. From pharmaceutical intermediates to next‑generation battery electrolytes and biodegradable plastics, 2‑MeTHF is helping companies around the world achieve efficient, safe, and truly green chemical solutions.
Product Details
| Product Name | 2-methyltetrahydrofuran CAS 96-47-9 |
| CAS NO. | 96-47-9 |
| Key words | 2-Methyltetrahydrofuran, 2-MeTHF for pharmaceuticals, 2-Methyltetrahydrofuran Grignard reaction |
| Molecular Formula | C5H10O |
| HS Number | 2932190090 |
| Structural Formula |  |
Specification
| Items | Standard |
| Appearance | Colourless, transparent liquid |
| Source | Biomass(corn cob) |
| Purity (%) | ≥99.5 |
| Moisture (%) | ≤ 0.03 |
| Density (g/cm³) | 0.86 |
| Boiling point | 78-80 |
Usage & Core function of 2-methyltetrahydrofuran CAS 96-47-9
1. Green solvent innovator: high-performance bio-based 2-methyltetrahydrofuran
A bio-based solvent designed specifically for Grignard reactions with >99.5% purity and 44% lower carbon footprint, helping pharma/electronics customers improve synthesis efficiency and ESG ratings.
2. Advantages of Grignard reaction performance
| Application Features | 2-MeTHF Effects | Pain points of traditional solvents |
| Reagent activity | Weak coordination → Grignard reagent yield 98%↑ | THF has strong coordination properties (yield 92%) |
| Moisture tolerance | Can contain trace amounts of water (≤0.1% is still stable) | Ether must be strictly anhydrous (easy to deactivate) |
| Post-processing efficiency | Forms an azeotrope with water → easy to recover by stratification | THF is completely miscible → high recycling cost |
| Security | Add BHT → Peroxide risk ↓ 90% | Ether is explosive → Nitrogen protection is required |
3. Typical application cases：Synthesis of pharmaceutical intermediates:
In the synthesis of the antimalarial drug primaquine phosphate, 2-MeTHF replaced ether as the Grignard reaction solvent, the reaction time was shortened by 40%, and the purity of primaquine was increased to 99.8%.
Production Capacity
Full-Cycle Safety Certifications
Recommended Product Applications
High-value intermediate synthesis
Pharmaceuticals and pesticides
Fragrances
New energy materials
New energy materials
Packing
Sealed in: 180kg Drum or 20mt ISO tank
If you require samples or small quantities of 2-Methyltetrahydrofuran (2-MeTHF), we offer a variety of packaging options to suit your needs.
FAQ
Q: What advantages does 2-MeTHF have in Grignard reactions compared to traditional solvents?
A: It improves Grignard reagent yield to 98%+, tolerates trace water (≤0.1%), eases solvent recovery, and reduces peroxide risk.
Q: What are the main application fields of 2-MeTHF?
A: It covers pharmaceuticals, OLED materials, new energy battery electrolytes, biodegradable plastics, etc.
Q: Why choose Shandong Yino?
A: 1. Stable supply and quality
The raw materials of 2-methyltetrahydrofuran, furfural and 2-methylfuran, are our commercial products. We guarantee a stable supply (annual output of 15,000 tons, the world's largest 2-methyltetrahydrofuran producer); self-production of raw materials also allows us to better control the quality stability.
2. The quality control department is independent of the factory and strictly controls the quality
3. The business covers the world, there are agents in ports around the world, and various trade terms are acceptable
4. Focus on environmental protection and sustainable development
There is a full set of waste gas, wastewater, and waste residue treatment, and recycling them to generate electricity.
Specification
| Items | Standard |
| Appearance | Colourless, transparent liquid |
| Source | Biomass(corn cob) |
| Purity (%) | ≥99.5 |
| Moisture (%) | ≤ 0.03 |
| Density (g/cm³) | 0.86 |
| Boiling point | 78-80 |
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