Pharmaceutical Intermediate Helper 2-MeTHF

2-Methyltetrahydrofuran (2-MeTHF) is a clear liquid with a characteristic ether-like smell, widely utilized as a specialty solvent in organic synthesis. Sourced from renewable biomass, it offers an eco-friendly and cost-efficient alternative to conventional solvents such as tetrahydrofuran (THF), diethyl ether, and dichloromethane. Compared to THF, 2-MeTHF has a higher boiling point, lower toxicity, and decreased solubility in water, which contributes to improved extraction capabilities and enhanced performance in both industrial and laboratory settings. Its hydrophobic properties, along with advantageous physical characteristics, make it a valuable solvent in sustainable and green chemistry practices.

In the production of pharmaceutical intermediates, 2-MeTHF plays a crucial role. It is widely used as a reaction medium in various organic synthesis processes. Its unique solubility properties allow for efficient dissolution of both organic substrates and organometallic reagents, promoting reaction rates and improving yields. Additionally, its low volatility and recyclability make it suitable for industrial-scale production, reducing environmental impact and production costs.

Product Name	Pharmaceutical intermediate helper 2-MeTHF | 2-methyltetrahydrofuran CAS 96-47-9
CAS NO.	96-47-9
Key words	2-Methyl tetrahydrofuran, 2-MeTHF for pharmaceuticals, Pharmaceutical intermediate helper 2-MeTHF
Molecular Formula	C5H10O
HS Number	2932190090
Structural Formula

1. Core Functions & Advantages

• Exceptional purity (≥99.5%) with ultra-low metals (≤0.1 ppb), ensuring ICH Q3D compliance for sensitive syntheses.
• Low water solubility and BHT stabilization, minimizing peroxide formation and explosion risks.
• Higher boiling point (80°C) than THF (66°C) or diethyl ether (35°C), reducing flammability and enabling safer handling.
• 44% lower carbon footprint vs. petroleum solvents, aligning with ESG/REACH goals.

2. Key Pharmaceutical Applications

• Grignard Reactions
• Solves: Low yields and strict anhydrous requirements.
• Advantage: Weak coordination boosts reagent yields to 98% (vs. 85% in ether) and tolerates ≤0.1% water, slashing drying costs.
• Use Case: Chloroquine synthesis (42% faster reactions, 92% yield).
• High-Purity Intermediates
• Solves: Metal contamination in catalysts/APIs.
• Advantage: Near-zero metal traces ensure compliance in OLED materials and antibiotics (e.g., cephalosporins).

2-MeTHF directly addresses pharma industry pain points:

1. Safety: BHT suppression of peroxides reduces storage/transport risks.

2. Efficiency: Water tolerance and easy recovery streamline manufacturing.

3. Sustainability: Bio-based origin future-proofs against carbon tariffs (e.g., EU CBAM).

4. Supply: 15,000-ton/year capacity (Shandong Yino) ensures batch consistency and global delivery.

Sealed in: 180kg Drum or 20mt ISO tank

If you require samples or small quantities of 2-Methyltetrahydrofuran (2-MeTHF), we offer a variety of packaging options to suit your needs.