Comprehensive Introduction
2-Methyltetrahydrofuran (2-MeTHF) is a bio-based, clear, and highly flammable liquid with an ether-like odor, commonly used as a solvent in organic synthesis. Serving as a sustainable replacement for traditional solvents such as tetrahydrofuran (THF) and dichloromethane, it offers numerous benefits: a higher boiling point, lower water solubility, reduced toxicity, and enhanced performance in both reactions and extractions. With excellent compatibility with organometallic reagents and a broad solubility range, 2-MeTHF is particularly valuable in pharmaceutical manufacturing, especially in the synthesis of complex active pharmaceutical ingredients (APIs). Environmentally friendly and readily recyclable, it aligns with green chemistry principles and is well-suited for both laboratory-scale and industrial-scale use.
Product Details
| Product Name | High purity 2-methyltetrahydrofuran | CAS 96-47-9 |
| CAS NO. | 96-47-9 |
| Key words | 2-Methyltetrahydrofuran, Biobased 2-methyltetrahydrofuran, High purity 2-methyltetrahydrofuran |
| Molecular Formula | C5H10O |
| HS Number | 2932190090 |
| Structural Formula |  |
Specification
|
Items |
Standard |
|
Appearance |
Colourless, transparent liquid |
|
Source |
Biomass(corn cob) |
|
Purity (%) |
≥99.5 |
|
Moisture (%) |
≤ 0.03 |
|
Density (g/cm³) |
0.86 |
|
Boiling point |
78-80 |
Impact of High-Purity 2-Methyltetrahydrofuran (2-MeTHF) on Reactions
1. Improves Reaction Selectivity and Yield
Impurities (such as water, peroxides, alcohols, and aldehydes) can interfere with catalysts or substrates, leading to side reactions. Using high-purity 2-MeTHF ensures more stable reaction conditions, especially for moisture-sensitive reactions (e.g., Grignard or organolithium reactions).
2. Enhances Catalyst Activity
Impurities can poison or deactivate catalysts, particularly metal-based ones (e.g., Pd, Ni, Cu). High-purity 2-MeTHF helps extend catalyst lifetime, reduce catalyst loading, and lower reaction costs.
3. Improves Process Reproducibility and Scalability
Inconsistent solvent purity may lead to batch-to-batch variability between lab-scale and industrial-scale production. Using high-purity solvents ensures better process control and reproducibility, complying with GMP and pharmaceutical manufacturing standards.
4. Reduces Risk of Hazardous Byproducts
Certain impurities can react with intermediates to form unstable or hazardous compounds, increasing safety risks. High-purity 2-MeTHF minimizes such risks, ensuring safer and more environmentally friendly reactions.
Key Advantages of High-Purity 2-MeTHF
|
Feature |
Advantage |
|
Low water content |
Prevents hydrolysis, suitable for moisture-sensitive systems |
|
Low peroxide content |
Reduces potential explosion risks and improves safety |
|
Moderate boiling point (~80°C) |
Facilitates solvent recovery and reuse, lowering costs |
|
Excellent solubility |
Compatible with a wide range of polar and non-polar compounds |
|
Good water immiscibility |
Allows easy extraction and phase separation, improving efficiency |
|
Derived from biomass |
Renewable and eco-friendly, aligned with green chemistry and ESG principles |
Application Examples (Brief)
|
Reaction Type |
Advantage Demonstrated |
|
Grignard reactions |
Anhydrous, high-purity solvent avoids side reactions and increases yield |
|
Organolithium reactions (e.g., n-BuLi) |
Stabilizes the system and improves reaction control |
|
Palladium-catalyzed couplings |
Minimizes interference from solvent impurities and boosts efficiency |
Production Capacity
Full-Cycle Safety Certifications
Recommended Product Applications
High-value intermediate synthesis
Pharmaceuticals and pesticides
Fragrances
New energy materials
Environmentally friendly polymers
Packing
Sealed in: 180kg Drum or 20mt ISO tank
If you require samples or small quantities of 2-Methyltetrahydrofuran (2-MeTHF), we offer a variety of packaging options to suit your needs.
FAQ
Q: Why is high-purity 2-MeTHF important in pharmaceutical synthesis?
A: High-purity 2-MeTHF ensures better reaction selectivity, catalyst performance, and reproducibility, especially in moisture-sensitive reactions like Grignard or organolithium synthesis.
Q: How does high-purity 2-MeTHF support green chemistry?
A: It is bio-based, recyclable, low in peroxides and water, and minimizes hazardous byproducts, aligning well with green and sustainable chemistry practices.
Q: Why choose Shandong Yino?
A: 1. Stable supply and quality
The raw materials of 2-methyltetrahydrofuran, furfural and 2-methylfuran, are our commercial products. We guarantee a stable supply (annual output of 15,000 tons, the world's largest 2-methyltetrahydrofuran producer); self-production of raw materials also allows us to better control the quality stability.
2. The quality control department is independent of the factory and strictly controls the quality
3. The business covers the world, there are agents in ports around the world, and various trade terms are acceptable
4. Focus on environmental protection and sustainable development
There is a full set of waste gas, wastewater, and waste residue treatment, and recycling them to generate electricity.
Specification
|
Items |
Standard |
|
Appearance |
Colourless, transparent liquid |
|
Source |
Biomass(corn cob) |
|
Purity (%) |
≥99.5 |
|
Moisture (%) |
≤ 0.03 |
|
Density (g/cm³) |
0.86 |
|
Boiling point |
78-80 |
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