Comprehensive Introduction
2-Methyltetrahydrofuran (2-MeTHF) is a clear, bio-based solvent with an ether-like odor, widely used in organic synthesis. It offers key advantages over traditional solvents such as THF and dichloromethane, including a higher boiling point, lower water solubility, reduced toxicity, and easier recovery. These properties make it ideal for use in both laboratory and industrial settings.
In addition to its growing role in pharmaceutical manufacturing-particularly in the synthesis of complex APIs-2-MeTHF is also used in the production of pesticide intermediates, where its strong solvating ability and process efficiency enhance reaction performance and product purity.
Product Details
| Product Name | High solubility 2-methyltetrahydrofuran | CAS 96-47-9 |
| CAS NO. | 96-47-9 |
| Key words | 2-Methyl tetrahydrofuran, 2-MeTHF for pesticides, High solubility 2-methyltetrahydrofuran |
| Molecular Formula | C5H10O |
| HS Number | 2932190090 |
| Structural Formula |  |
Specification
|
Items |
Standard |
|
Appearance |
Colourless, transparent liquid |
|
Source |
Biomass(corn cob) |
|
Purity (%) |
≥99.5 |
|
Moisture (%) |
≤ 0.03 |
|
Density (g/cm³) |
0.86 |
|
Boiling point |
78-80 |
Impact and Advantages of High Solubility of 2-Methyltetrahydrofuran (2-MeTHF)
1. Improved Reactant Solubility Enhances Reaction Efficiency
2-MeTHF exhibits excellent solubility, capable of dissolving both polar and non-polar compounds. This allows reactants to be more evenly dispersed in the solvent, promoting better contact and more complete reactions, thereby increasing reaction rate and yield.
2. Broad Applicability Across Diverse Reaction Systems
Whether in nucleophilic substitution, organometallic reactions, asymmetric catalysis, or reduction processes, 2-MeTHF provides a favorable solvation environment for substrates, catalysts, or intermediates. It is especially useful for heterocycles, organometallic reagents, and complex natural product intermediates, which often have varied polarity and complex structures.
3. Enhances Extraction and Purification Processes
Its strong ability to dissolve organic products improves extraction efficiency during post-reaction workup. Especially beneficial in natural product extraction and purification of pharmaceutical intermediates.
4. Reduces or Replaces Use of Toxic Solvents
Thanks to its high solubility and green profile, 2-MeTHF can serve as a safer alternative to traditional toxic solvents like DMF, DMSO, and dichloromethane, reducing environmental and health hazards.
Production Capacity
Full-Cycle Safety Certifications
Recommended Product Applications
High-value intermediate synthesis
Pharmaceuticals and pesticides
Fragrances
New energy materials
Environmentally friendly polymers
Packing
Sealed in: 180kg Drum or 20mt ISO tank
If you require samples or small quantities of 2-Methyltetrahydrofuran (2-MeTHF), we offer a variety of packaging options to suit your needs.
FAQ
Q: What advantage does 2-MeTHF's high solubility offer in synthesis?
A: Its ability to dissolve both polar and non-polar compounds enhances reaction rates, yields, and extraction efficiency in complex organic reactions.
Q: Can 2-MeTHF replace more toxic solvents?
A: Yes, 2-MeTHF serves as a safer, greener alternative to solvents like DMSO, DMF, and dichloromethane, reducing environmental and health risks.
Q: Why choose Shandong Yino?
A: 1. Stable supply and quality
The raw materials of 2-methyltetrahydrofuran, furfural and 2-methylfuran, are our commercial products. We guarantee a stable supply (annual output of 15,000 tons, the world's largest 2-methyltetrahydrofuran producer); self-production of raw materials also allows us to better control the quality stability.
2. The quality control department is independent of the factory and strictly controls the quality
3. The business covers the world, there are agents in ports around the world, and various trade terms are acceptable
4. Focus on environmental protection and sustainable development
There is a full set of waste gas, wastewater, and waste residue treatment, and recycling them to generate electricity.
Specification
|
Items |
Standard |
|
Appearance |
Colourless, transparent liquid |
|
Source |
Biomass(corn cob) |
|
Purity (%) |
≥99.5 |
|
Moisture (%) |
≤ 0.03 |
|
Density (g/cm³) |
0.86 |
|
Boiling point |
78-80 |
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