High Boiling Point 2-methyltetrahydrofuran

2-Methyltetrahydrofuran (2-MeTHF) is a clear, bio-based, with an ether-like odor, widely employed in organic synthesis. As a sustainable alternative to conventional solvents like tetrahydrofuran (THF) and dichloromethane, it provides several key advantages: a higher boiling point, lower water solubility, reduced toxicity, and greater efficiency in extractions and chemical reactions. Its strong compatibility with organometallic reagents and broad solubility make it particularly valuable in pharmaceutical production, including the synthesis of complex active pharmaceutical ingredients (APIs). Environmentally friendly and easily recyclable, 2-MeTHF supports green chemistry practices and is suitable for both laboratory research and large-scale industrial applications.

Product Name	High boiling point 2-methyltetrahydrofuran | CAS 96-47-9
CAS NO.	96-47-9
Key words	2-Methyltetrahydrofuran, Bio-based 2-methyltetrahydrofuran, High boiling point 2-methyltetrahydrofuran
Molecular Formula	C5H10O
HS Number	2932190090
Structural Formula

2-Methyltetrahydrofuran (2-MeTHF) has a higher boiling point (~80°C) compared to traditional solvents like THF (~66°C). This property brings several important benefits and influences in organic synthesis:

1. Wider Reaction Temperature Range
The higher boiling point allows reactions to proceed at elevated temperatures without excessive solvent evaporation or pressure buildup. It is especially suitable for heated reactions such as reductions, couplings, condensations, and ring-opening polymerizations, enhancing both reaction rate and conversion.

2. Improved Reaction Efficiency and Kinetics
Higher temperatures increase molecular collision frequency, accelerating reaction kinetics. This is particularly advantageous for low-reactivity or slow-transforming substrates.

3. Reduced Solvent Loss and Easier Recovery
Compared to lower boiling point solvents, 2-MeTHF is less volatile during reactions, reducing solvent loss. It is easier to condense and recover, making it ideal for reuse in continuous or closed-system processes-supporting green chemistry.

4. Better for Flow Chemistry and Scale-Up
The higher boiling point minimizes internal vapor pressure fluctuations, allowing more precise control of temperature and pressure in reactors. Well-suited for flow chemistry systems, pressure vessels, and large-scale production setups.

5. Enhanced Extraction and Separation Flexibility
In solvent extraction, the high boiling point allows for stable performance at elevated temperatures, making it suitable for hot extraction or thermal processing, increasing process versatility.

Sealed in: 180kg Drum or 20mt ISO tank

If you require samples or small quantities of 2-Methyltetrahydrofuran (2-MeTHF), we offer a variety of packaging options to suit your needs.