Comprehensive Introduction
3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) is a colorless, flammable liquid with a mild ether-like odor and serves as a foundational intermediate in organic synthesis. As a six-membered heterocyclic ether, DHP is best known for its role in protecting alcohol functionalities through tetrahydropyranyl (THP) ether formation. This makes it indispensable in multi-step synthesis of pharmaceuticals, natural products, and specialty chemicals.
Produced via catalytic hydrogenation of dihydropyran or biomass-derived furfural, DHP aligns well with the needs of sustainable chemistry. Its core properties-base stability, acid sensitivity, and volatility-also support its application in resins, coatings, and fine chemical production.
Product Details
| Product Name | 3,4-Dihydro-2H-pyran CAS 110-87-2 |
| CAS NO. | 110-87-2 |
| Synonyms | DHP |
| Molecular Formula | C5H8O |
| HS Code | 2932999099 |
| Structural Formula |  |
Specification
|
Items |
Standard |
|
Appearance |
Colorless transparent liquid |
|
Purity (%) |
≥98.5 |
|
Moisture (%) |
≤0.25 |
|
THP(%) |
1.3 max |
|
Flash Point |
~-6°C (closed cup) |
|
Odor |
Ether-like |
|
Packaging |
180 kg drums, lab bottles |
| Density (g/cm³) | 0.922 |
Usage & Core Function of 3,4-Dihydro-2H-pyran CAS 110-87-2
(A Versatile Intermediate for Advanced Synthesis)
- Alcohol Protection in Organic Synthesis:
DHP forms THP ethers with alcohols under mild acid catalysis, rendering alcohols inert to nucleophiles and bases during complex synthetic procedures. THP groups are easily removed using dilute acids.
- Multistep Drug Synthesis:
Used in the synthesis of steroids, HIV protease inhibitors, and macrolide antibiotics by selectively masking hydroxyl groups.
- Intermediate in Industrial Chemicals:
Precursor in the synthesis of flavors, fragrances (e.g., musk compounds), and agrochemicals.
- Polymer and Resin Chemistry:
Provides cyclic ether building blocks for high-performance coatings and UV-curable systems.
- Biomass-Derived Platform Molecule:
DHP can be synthesized from furfural, making it a viable intermediate in bio-based solvent and additive development.
Production Capacity
Full-Cycle Safety Certifications
Recommended Product Applications
Pharmaceutical synthesis (e.g., erythromycin, corticosteroids)
Agrochemical intermediates
Sugar protection in carbohydrate chemistry
UV-curable coatings and high-flex resins
Fuel additive synthesis (e.g., solketal route)
Fragrance compound development
Comparison of DHP in Different Grades:
Packing:
Sealed in: 180 kg drums (industrial), 1L/5L bottles (lab scale)
FAQ
Q: What is the main use of DHP in organic chemistry?
A: It is primarily used to protect alcohol groups as THP ethers during synthesis. This allows selective reactions to occur without interference from hydroxyl groups.
Q: Is DHP derived from renewable sources?
A: Yes. DHP can be produced from furfural, which is sourced from agricultural biomass waste like corncobs and bagasse.
Q: How is the THP group removed?
A: THP groups are removed using dilute aqueous acid, regenerating the original alcohol with minimal side reactions.
Specification
|
Items |
Standard |
|
Appearance |
Colorless transparent liquid |
|
Purity (%) |
≥98.5 |
|
Moisture (%) |
≤0.25 |
|
THP(%) |
1.3 max |
|
Flash Point |
~-6°C (closed cup) |
|
Odor |
Ether-like |
|
Packaging |
180 kg drums, lab bottles |
| Density (g/cm³) | 0.922 |
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