Comprehensive Introduction
3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) is a vital pharmaceutical intermediate prominently used in active pharmaceutical ingredient (API) synthesis. This six-membered heterocyclic ether serves a critical function as a protecting agent for hydroxyl groups through the formation of tetrahydropyranyl (THP) ethers. Its ability to mask alcohol functionalities under mild acidic conditions and revert them cleanly under aqueous acid makes it essential in multistep drug synthesis.
Manufactured via hydrogenation of dihydropyran or biomass-derived furfural, DHP aligns with green chemistry principles. Its dual role as a protecting reagent and reactive intermediate has cemented its value in the production of corticosteroids, macrolide antibiotics, and HIV protease inhibitors, among other high-value APIs.
Product Details
| Product Name | 3,4-Dihydro-2H-pyran |
| CAS NO. | 110-87-2 |
| Synonyms | DHP |
| Molecular Formula | C5H8O |
| HS Code | 2932999099 |
| Structural Formula |  |
Specification
|
Items |
Standard |
|
Appearance |
Colorless transparent liquid |
|
Purity (%) |
≥98.5 |
|
Moisture (%) |
≤0.25 |
|
THP(%) |
1.3 max |
| Density (g/cm³) | 0.922 |
Usage & Core Function in Pharmaceutical Synthesis
- Hydroxyl Protection in API Development:
DHP is used to selectively protect alcohol groups in drug intermediates as THP ethers. These groups are stable under basic and nucleophilic conditions and can be removed cleanly using dilute acids.
- Multistep Organic Synthesis:
Facilitates synthesis routes where alcohol-containing intermediates must undergo further functionalization without side reactions.
- Key Applications in Drug Synthesis:
Erythromycin (macrolide antibiotic): DHP used for selective hydroxyl protection during ring formation.
Corticosteroids: Protects hydroxyl groups during complex ring rearrangements and oxidation steps.
HIV Protease Inhibitors: In peptidomimetic drugs, DHP helps stabilize side chains during condensation and cyclization.
- Green Chemistry Intermediate:
Can be derived from furfural-a biomass-based chemical-positioning DHP as a sustainable intermediate for pharmaceutical use.
Production Capacity
Full-Cycle Safety Certifications
Recommended Product Applications
Synthesis of macrolides and aminoglycosides
Steroidal drug synthesis (e.g., hydrocortisone, dexamethasone)
Peptide and peptidomimetic drug development
Selective hydroxyl protection in carbohydrate-based drug scaffolds
Process chemistry for scale-up of clinical candidates
Packing
Sealed in: 180 kg drums (bulk), 1L/5L bottles (laboratory or pilot scale)
FAQ
Q: Why is DHP important in pharmaceutical synthesis?
A: It enables selective protection of hydroxyl groups, allowing multistep drug synthesis to proceed efficiently without side reactions.
Q: Can DHP be used in GMP processes?
A: Yes. High-purity pharma-grade DHP is suitable for regulated environments when supported by validated specifications and COAs.
Q: How is THP protection reversed in drug synthesis?
A: THP groups are removed using mild acid (e.g., aqueous acetic acid), restoring the free alcohol for subsequent steps.
Specification
|
Items |
Standard |
|
Appearance |
Colorless transparent liquid |
|
Purity (%) |
≥98.5 |
|
Moisture (%) |
≤0.25 |
|
THP(%) |
1.3 max |
| Density (g/cm³) | 0.922 |
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