Comprehensive Introduction
High-purity 3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) is a refined grade reagent used in precision organic synthesis, pharmaceutical manufacturing, and high-value chemical applications. With a purity of ≥99.5%, this version of DHP is specifically engineered for low-impurity workflows, including GMP-supporting synthesis and sensitive multistep transformations such as protecting hydroxyl groups as tetrahydropyranyl (THP) ethers.
This grade ensures minimal side reactions, enhanced stability, and regulatory compatibility-making it ideal for chiral chemistry, peptide intermediates, and clean deprotection pathways in downstream synthesis.
Product Details
| Product Name | High-Purity 3,4-Dihydro-2H-pyran |
| CAS NO. | 110-87-2 |
| Synonyms | DHP |
| Molecular Formula | C5H8O |
| HS Code | 2932.19.00 |
| Structural Formula |  |
Specification
|
Items |
Standard |
|
Appearance |
Colorless transparent liquid |
|
Purity (%) |
≥98.5 |
|
Moisture (%) |
≤0.25 |
|
THP(%) |
1.3 max |
| Density (g/cm³) | 0.922 |
Usage & Core Function
(A Premium Reagent for High-Fidelity Hydroxyl Protection)
- Precise Alcohol Protection: Converts alcohols into THP ethers with high selectivity and minimal side reactions.
- Ultra-Clean Reactions: Ensures high yields in sensitive reactions including chiral, peptidic, or nucleoside derivatives.
- Regulatory-Grade Intermediate: Suitable for regulated drug development and pilot-scale production.
- Specialty Performance: Also used in advanced coatings and resin applications where impurity sensitivity is high.
Production Capacity
Full-Cycle Safety Certifications
Recommended Applications
Chiral alcohol and amino alcohol protection
GMP-compliant pharmaceutical intermediate synthesis
Peptide and sugar chemistry workflows
UV monomer and resin systems with purity-critical demands
Scale-up and registration studies (clinical APIs)
FAQ
Q: What is high-purity DHP used for?
A: For precision protection of alcohols in pharmaceuticals, particularly where impurity sensitivity and reproducibility are critical.
Q: How is it different from regular DHP?
A: It features significantly lower impurities and is tested to stricter standards, making it fit for GMP or highly sensitive synthesis.
Q: Can this be used in commercial drug synthesis?
A: Yes-especially in validated environments with COA and traceability compliance.
Specification
|
Items |
Standard |
|
Appearance |
Colorless transparent liquid |
|
Purity (%) |
≥98.5 |
|
Moisture (%) |
≤0.25 |
|
THP(%) |
1.3 max |
| Density (g/cm³) | 0.922 |
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