Comprehensive Introduction
High-stability 3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) is a specially stabilized grade of this critical cyclic ether used in synthetic chemistry. DHP is valued for its ability to form tetrahydropyranyl (THP) ethers-a widely used strategy for hydroxyl group protection in pharmaceuticals, peptides, and carbohydrate chemistry.
In its high-stability formulation, DHP is inhibited to reduce polymerization, allowing for improved shelf-life, thermal resistance, and transport safety. This is particularly important for bulk storage, export shipments, and environments where DHP may be exposed to heat, moisture, or acidic vapors. The stabilized variant maintains full reactivity while reducing degradation or viscosity increase over time.
Product Details
| Product Name | High-Stability 3,4-Dihydro-2H-pyran |
| CAS NO. | 110-87-2 |
| Synonyms | DHP, THP precursor, stabilized DHP |
| Molecular Formula | C5H8O |
| HS Code | 2932999099 |
| Structural Formula |  |
Specification
|
Items |
Standard |
|
Appearance |
Colorless transparent liquid |
|
Purity (%) |
≥98.5 |
|
Moisture (%) |
≤0.25 |
|
THP(%) |
1.3 max |
| Density (g/cm³) | 0.922 |
Usage & Core Function of High-Stability DHP
(Formulated for Storage, Bulk Handling & Extended Reactivity)
- THP Ether Formation in Multistep Synthesis:
DHP reacts with alcohols under acid catalysis to form THP ethers. The high-stability grade retains this function without premature polymerization.
- Bulk Storage & Transportation:
Stabilization prevents auto-polymerization, gelling, or yellowing during extended storage or international shipping.
- Improved Handling Safety:
Inhibitor limits exothermic degradation during exposure to heat, acids, or UV.
- No Performance Compromise:
Fully compatible with standard reaction conditions; stabilizer is removed or consumed during acid-catalyzed ether formation.
Production Capacity
Full-Cycle Safety Certifications
Recommended Product Applications
Bulk procurement for pharmaceutical and fine chemical plants
Warehouse/long-term supply chains in warm or humid climates
THP protection workflows in pilot plants and scale-up batches
Resin, monomer, or UV-cured formulations requiring THP building blocks
Export shipments and toll manufacturing partners
FAQ
Q: What makes this DHP more stable?
A: It includes trace stabilizers (e.g., BHT) that inhibit spontaneous polymerization, especially under acidic or warm conditions.
Q: Will the stabilizer interfere with THP ether formation?
A: No. The stabilizer is either consumed or does not interfere under standard acidic conditions used for alcohol protection.
Q: Can this be used in pharmaceutical synthesis?
A: Yes. It is recommended to verify stabilizer compatibility with your specific application, especially in regulated environments.
Specification
|
Items |
Standard |
|
Appearance |
Colorless transparent liquid |
|
Purity (%) |
≥98.5 |
|
Moisture (%) |
≤0.25 |
|
THP(%) |
1.3 max |
| Density (g/cm³) | 0.922 |
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