DHP in Organic Synthesis

3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) is a highly valuable intermediate and reagent in organic synthesis, especially recognized for its role as an alcohol-protecting agent. As a six-membered unsaturated cyclic ether, DHP forms tetrahydropyranyl (THP) ethers when reacted with alcohols under acidic conditions. This protection strategy is crucial in multistep synthesis to prevent unwanted reactions at hydroxyl sites while maintaining compatibility with basic and nucleophilic reagents.

DHP is a colorless, low-boiling liquid produced via hydrogenation of dihydropyran or renewable furfural. Its reactive vinyl ether structure enables selective modification and controlled transformation of organic molecules, making it indispensable in modern synthetic chemistry labs and pharmaceutical R&D pipelines.

Product Name	DHP in organic sythesis CAS 110-87-2
CAS NO.	110-87-2
Synonyms	DHP
Molecular Formula	C5H8O
HS Code	2932999099
Structural Formula

• THP Ether Formation (Alcohol Protection):

DHP reacts with primary and secondary alcohols in the presence of an acid catalyst (e.g., p-TsOH, HCl) to form THP ethers. These protect hydroxyl groups from oxidation, acylation, or alkylation in subsequent steps.

• Selective Deprotection:

THP groups are easily removed using mild acid (e.g., acetic acid in water or TFA), providing excellent orthogonality in protecting group strategies.

• Applications in Complex Molecule Synthesis:

Natural products: THP ethers stabilize multifunctional intermediates.

Peptides and carbohydrates: Selective protection of hydroxyl-bearing side chains and sugar alcohols.

API synthesis: Used in drugs like erythromycin, steroids, and alkaloids.

• Stability Advantages:

THP ethers are stable under basic, reductive, and mild oxidative conditions, allowing reactions such as Grignard additions, base-promoted condensations, and metal-catalyzed couplings.

Available in: 180 kg drums, 1L or 5L glass bottles for laboratory use